According to “Megadeath” at Discover.com it was a hemorraghic fever, native to Mexico and only found when severe drought is followed by a wet period. The Aztecs knew smallpox; they even had their own name for it. But the horrible death that wiped most of them out, they called something else.
It is fascinating reading. (If you don’t have time to read the whole thing, Comment 2 has relevant short quotes from the article.)
Thanks to Mirabilis for the pointer.
what did wipe out the aztecs?
“The cocolitzli plagues of the mid-16th century probably had nothing to do with smallpox. In fact, they probably had little to do with the Spanish invasion. But they probably did have an origin that is worth knowing about in 2006.”
The fevers were contagious, burning, and continuous, all of them pestilential, in most part lethal. The tongue was dry and black. Enormous thirst. Urine of the colors of sea-green, vegetal green, and black, sometimes passing from the greenish color to the pale. Pulse was frequent, fast, small, and weak—sometimes even null. The eyes and the whole body were yellow. This stage was followed by delirium and seizures. Then, hard and painful nodules appeared behind one or both ears along with heartache, chest pain, abdominal pain, tremor, great anxiety, and dysentery. The blood that flowed when cutting a vein had a green color or was very pale, dry, and without serosity. . . . Blood flowed from the ears and in many cases blood truly gushed from the nose. . . . This epidemic attacked mainly young people and seldom the elder ones.
“This was certainly not smallpox,” Acuña-Soto says. “If they described something real, then it appeared to be a hemorrhagic fever.”
“If cocolitzli had been caused by a hemorrhagic virus, Acuña-Soto realized, the Spanish could not have brought it with them. Such diseases do not readily pass from one person to another, so the virus must have been native. ”
So, according to the article, it was a native hemorraghic fever (which is not spread easily one human to another) that almost wiped out the Aztecs and allowed the Spaniards to conquer them fairly easily.